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One mechanism of resistance of prostate cancer (PCa) to enzalutamide (MDV3100) treatment is the increased expression of AR variants lacking the ligand binding domain, the best characterized of which is AR V7. We have previously reported that Phosphatidylinositol 4 phosphate 5 kinase alpha (PIP5K), is a lipid kinase that links to CDK1 and AR pathways. […]


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