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For two Y1 receptor heterodimer combinations (with the Y4 receptor or 2 adrenoceptor), agonist and antagonist pharmacology was explained by independent actions on the respective orthosteric binding sites. However, Y1/Y5 receptor BiFC dimers, compared with the constituent subtypes, were characterized by reduced potency and efficacy of Y5 selective peptide agonists, the inactivity of Y1 selective antagonists, and a change from surmountable to nonsurmountable antagonism for three unrelated Y5 antagonists. Thus, allosteric interactions between Y1 and Y5 receptors modify the pharmacology of the heterodimer, with implications for potential antiobesity agents that target centrally coexpressed Y1 and Y5 receptors to suppress appetite..
Understanding the use of electrical appliances in households is crucial for improving the accuracy of electricity and energy loads forecasts. In particular, bottom up techniques provide a powerful tool, not only for predicting demands considering socio demographic characteristics of the occupants, but also to better resolve and implement demand side management strategies in homes.With this purpose, a study of the temporal energy use of low load appliances (meaning those whose annual energy share is individually negligible but relevant when considered as a group) has been carried out, with the longer term objective of finding a parsimonious approach to modelling them, and which considers an appropriate aggregation of appliances. In this work, a discrete time stochastic process has been implemented for a specific classification of low load appliances.